Vertical vs Horizontal Implementation of O-TLM (037)

This study is testing two different strategies to implement an Opioid Treatment Linkage Model (O-TLM). The model is designed to link individuals under community supervision with appropriate community-based treatment services. O-TLM seeks to improve interagency collaboration through staff training and cross-system data sharing.

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Testing XR:NTX vs XR:B (Sublocade) (035)

This study is conducting a large multisite trial to compare the effectiveness of extended-release buprenorphine (Sublocade, XR-B) to extended-release naltrexone (XR-NTX). The trial will enroll individuals prior to release from jail and randomize to either medication option. The first dose of medication will be administered prior to release, with an additional 24 weeks of treatment received in the community.

Participating jails are located in Connecticut, Delaware, New Hampshire, New Jersey and Oregon. The study will measure retention in treatment, and opioid and other substance use outcomes between the two medication conditions, as well as a sample of individuals who opt for other treatment options (“treatment as usual”).

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XR:NTX vs XR:B (Brixadi) (034)

This study is conducting a comparative effectiveness trial of extended-release naltrexone (XR-NTX) versus a new extended-release formulation of buprenorphine (Brixadi, XR-B) to treat opioid use disorder (OUD) among justice-involved individuals in ten Maryland county jails.

Participants will be randomly assigned to receive either XR-NTX or XR-B prior to release from jail, followed by six monthly injections while in the community. The goal of the study is to evaluate the effectiveness of the two medications, measure medication adherence, and gather data to inform broader scale-up of medications for opioid use disorder (MOUD) in jails and in the community.

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Standard vs Adaptive Recovery Management Checkups (033)

This study is comparing the effectiveness of the Recovery Management Checkups (RMC) model, an evidence-based intervention that provides regular, fixed schedule check-ups to support treatment retention and recovery, and an adaptive model (RMC-Adapted) that tailors checkup frequency and intensity to individuals’ needs. Each condition offers justice-involved individuals referral or assertive linkage to a designated treatment provider upon release from jail.

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Evaluation of Massachusetts State-Mandated Pilot of MOUD in Jails (032)

A 2018 Massachusetts law (“Chapter 208”) established a 4-year pilot program to expand the use of all FDA-approved forms of medications for opioid use disorder (MOUD) at five county jails; two additional jails voluntarily joined this pilot. The law stipulates that MOUD be maintained in individuals who were already receiving it prior to detention; initiated prior to release from jail when appropriate; and continued in the community via facilitated linkages to local services after release. The Massachusetts Hub will conduct a longitudinal treatment outcome study of individuals in these jails to examine MOUD initiation, engagement and retention, as well as fatal and non-fatal overdose and recidivism. The study will also identify strategies associated with the successful implementation of MOUD and inform the development of future strategies to address opioid use disorder in jails nationwide.

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Implementing an Opioid Court Model (031)

This study is evaluating strategies to implement New York’s new opioid court model (OCM) in ten counties across the state. New York’s OCM was developed by the Unified Court System and provides practice guidelines for drug courts to reduce overdose, decrease recidivism, and improve service delivery and linkages to medications for opioid use disorder (MOUD) for justice-involved individuals across the state. The goal of the study is to develop, evaluate, and refine implementation strategies to support the OCM practice guidelines to be scaled up across New York.

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MOUD + Pre-Treatment Telehealth for Women Leaving Jail (030)

This study will evaluate the effectiveness of initiating treatment services through telehealth and peer navigation for justice-involved women with opioid use disorder (OUD) as they transition from jail to the community. Through these services, participants will be able to engage with community health providers and peer navigators prior to release.

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