NIATx vs ECHO as Comparative Implementation Strategies (041)

The trial will test two timely and successful evidence-based implementation practices, NIATx Coaching and Extension for Community Healthcare Outcomes (ECHO), with jail and community-based treatment providers to increase MOUD use with justice populations. NIATx Coaches provide expertise in MOUD implementation and organizational change to help treatment organizations and staff make, sustain, and spread MOUD. The ECHO platform focuses on the provider side by connecting primary care providers with expert MOUD prescribers to promote high-quality MOUD practices. This will be the first trial that assesses the comparative effectiveness of these approaches overall, and in justice settings.

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Arnold/BJA Bridges Project Evaluation (009)

This supplement is to conduct an implementation process evaluation for the Bureau of Justice Assistance (BJA) and Arnold Ventures’ “Planning Initiative to Build Bridges between Jail and Community-Based Treatment for Opioid Use Disorder.” The goal of the 9-month planning initiative is to help 16 communities develop a continuum of care for providing medications for opioid use disorder (MOUDs) in jails and extending services into the community, bridging jails, community corrections, and community treatment providers.

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Reducing Opioid Mortality in Illinois (ROMI) (040)

This study is conducting a multi-site trial called ROMI (Reducing Opioid Mortality in Illinois) to study the effectiveness of case management approaches to link individuals with community-based treatment services upon release from jail. The ROMI intervention includes peer recovery coaches to improve linkages to medications for opioid use disorder (MOUD), supportive services, naloxone distribution, and harm reduction services for justice-involved individuals with opioid use disorder (OUD).

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Transitions Clinic Network vs Standard Care at Re-Entry (038)

The study will assess whether the Transitions Clinic Network (TCN) program, which provides enhanced primary care and OUD treatment for people recently released from incarceration, improves services along the opioid treatment cascade. In TCN, formerly incarcerated community health workers are embedded within primary care teams and address social determinants of OUD, provide social support, help patients build trust in the health system, and advocate in interactions with the criminal justice system.

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XR:NTX vs XR:B (Brixadi) (034)

This study is conducting a comparative effectiveness trial of extended-release naltrexone (XR-NTX) versus a new extended-release formulation of buprenorphine (Brixadi, XR-B) to treat opioid use disorder (OUD) among justice-involved individuals in ten Maryland county jails.

Participants will be randomly assigned to receive either XR-NTX or XR-B prior to release from jail, followed by six monthly injections while in the community. The goal of the study is to evaluate the effectiveness of the two medications, measure medication adherence, and gather data to inform broader scale-up of medications for opioid use disorder (MOUD) in jails and in the community.

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Standard vs Adaptive Recovery Management Checkups (033)

This study is comparing the effectiveness of the Recovery Management Checkups (RMC) model, an evidence-based intervention that provides regular, fixed schedule check-ups to support treatment retention and recovery, and an adaptive model (RMC-Adapted) that tailors checkup frequency and intensity to individuals’ needs. Each condition offers justice-involved individuals referral or assertive linkage to a designated treatment provider upon release from jail.

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MOUD + Pre-Treatment Telehealth for Women Leaving Jail (030)

This study will evaluate the effectiveness of initiating treatment services through telehealth and peer navigation for justice-involved women with opioid use disorder (OUD) as they transition from jail to the community. Through these services, participants will be able to engage with community health providers and peer navigators prior to release.

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