DAT-Optimizing the Impact of Medication Assisted Treatment Interventions in Prison and Jail Settings (008)

This supplement expands on the scientific impact of the parent grant (1R21DA044443-01) by estimating the impact of expanded access to medications for addiction treatment (MAT) in prisons and jails on post-release rates of overdose. Led by Miriam Hospital, this project used agent-based modeling, data collected through the parent study, existing surveillance data in Rhode Island (RI), and recently-published data from similar settings to understand how different MAT interventions in prison and jail setting impact overdose death post-release. Researchers utilized an agent-based model using historical data on overdose fatality rates in RI to forecast the number of opioid overdose fatalities over an eight year period (2017-2025) under four different MAT strategies. State surveillance data from the four years preceding implementation of the comprehensive MAT program (2012-2016) will be used to calibrate the model. In order to compare the different strategies, researchers will calculate and compare the total number of overdose fatalities statewide as well as the number of overdose fatalities among those being released from correctional facilities over the eight year period.

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In Silico JCOIN Trial Models (018)

Computational analogues of the JCOIN clinical research centers, so called in silico clinical trials, in the form of data-driven, agent-based network models (ABNMs), can provide a variety of simulation-based analyses to investigate longer-term health outcomes beyond the clinical trial timelines. Building on the Justice-Community Circulation Model (JCCM), the University of Chicago will apply the JCCM framework to develop in silico versions of JCOIN’s clinical research trials to run computational trials such as optimizing cross-study combinations of interventions or tracking additional and emerging outcome.

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Justice-Community Circulation Model (017)

The University of Chicago is developing an agent-based network model (ABNM) framework to study location-specific evolution and dynamics of opioid use disorder (OUD) in justice settings. The Justice Community Circulation Model framework is designed to help researchers and practitioners explore underlying mechanisms, epidemiological processes and interactions, such as the health and mortality pathways of individuals who experience non-fatal overdose or who initiate treatment, among justice-involved individuals with OUD.

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