Strengthening Buprenorphine Treatment for Individuals in Carceral Settings (STAND): A Hybrid Implementation-Effectiveness Trial of Long-Acting Injectable Versus Sublingual Buprenorphine
Study Information
This study is a large hybrid type 1 effectiveness-implementation randomized controlled trial evaluating the comparative effectiveness of long-acting injectable buprenorphine (XRB) versus sublingual buprenorphine (SLB) among incarcerated adult volunteers with opioid use disorder (OUD) who are preparing for release. The study addresses the urgent need for high-quality data comparing these two buprenorphine formulations in corrections-to-community transitions, where individuals face heightened risks for overdose and poor treatment engagement. Using random assignment, the study team is tracking how well participants adhere to their treatment plans 12 weeks after leaving prison. They monitor substance use and overdose incidents and gather feedback from participants about their experiences, as well as assess the cost and feasibility of implementing these treatments in a correctional setting.
Grant number: 1UM1DA064531
Link to NIH Reporter record: https://reporter.nih.gov/search/Nta9OCNczUCyGuUfSsToqQ/project-details/11262610
Study Team
PI: Josh Lee, Lisa Marsch, Sandra Springer, Jan Gryczynski
- Compare effectiveness of XRB vs. SLB for buprenorphine treatment retention at 12 weeks post-release of volunteer individuals
- Evaluate implementation, feasibility, and relative costs of XRB vs. SLB
- Conduct pilot studies and cross-Hub analysis as a Network collaboration
Hybrid Type 1 Implementation Effectiveness Randomized Controlled Trial