Clinical trials form the bedrock of evidence-based healthcare interventions. However, they come with associated time, cost and logistical burdens. Simulation-based approaches can complement or extend clinical trial investigations by providing the ability to run synthetic analogues of clinical trials that would not be practical (or ethical) to conduct in the real world. This project will apply the Justice-Community Circulation Model (JCCM) agent-based modeling (ABM) framework to develop in silico versions of the Hub clinical trials. This will allow for running computational trials for, for example, assessing the impacts of cross-Hub combinations of interventions or observing possible longer-term health outcomes beyond the clinical trial timelines. This capability will also potentially aid in future clinical trial design.