XR:NTX vs XR:B (Brixadi) (034)

This study is conducting a comparative effectiveness trial of extended-release naltrexone (XR-NTX) versus a new extended-release formulation of buprenorphine (Brixadi, XR-B) to treat opioid use disorder (OUD) among justice-involved individuals in ten Maryland county jails.

Participants will be randomly assigned to receive either XR-NTX or XR-B prior to release from jail, followed by six monthly injections while in the community. The goal of the study is to evaluate the effectiveness of the two medications, measure medication adherence, and gather data to inform broader scale-up of medications for opioid use disorder (MOUD) in jails and in the community.

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Implementing an Opioid Court Model (031)

This study is evaluating strategies to implement New York’s new opioid court model (OCM) in ten counties across the state. New York’s OCM was developed by the Unified Court System and provides practice guidelines for drug courts to reduce overdose, decrease recidivism, and improve service delivery and linkages to medications for opioid use disorder (MOUD) for justice-involved individuals across the state. The goal of the study is to develop, evaluate, and refine implementation strategies to support the OCM practice guidelines to be scaled up across New York.

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