Research

JCOIN includes 13 clinical research centers (“Research Hubs”), that are studying evidence-informed approaches to ensure quality care is provided to individuals with opioid use disorder in justice settings, and two resource centers that conduct complementary studies and provide supportive infrastructure: the Coordination and Translation Center (CTC) and the Methodology and Advanced Analytics Resource Center (MAARC).

JCOIN Studies

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Publications Library

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Research Translation

Breakdowns of research regarding substance use disorders within health and justice settings.

JCOIN Studies

Each JCOIN study brings researchers together with justice and health stakeholders in five or more communities to address gaps in opioid use disorder treatment and related services. Their work engages a wide range of justice settings, including jails, prisons, community corrections, problem-solving courts, and juvenile justice agencies. The studies evaluate behavioral interventions, digital therapeutics, comprehensive patient-centered treatments, and delivery of medications for opioid use disorder (MOUD) throughout the United States.

In 2018-2020, JCOIN supported 15 accelerator supplement projects, which included short-term studies and surveys.

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Reducing Stigma Among Individuals with Addiction and Staff in the CJ System (053)

Principal Investigator(s): Kelly Moore

This project addresses stigma associated with addiction, MOUD, and criminal involvement in the CJ system. It draws upon existing evidence-based interventions to develop a multi-level stigma intervention, Combatting Stigma to Aid Re-entry and Recovery (CSTARR), that simultaneously targets CJ staff attitudes as well as CJ-involved individuals’ ability to cope with stigma. The study uses a…

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Veteran’s Court Study (052)

Principal Investigator(s): James Byrne, Faye Taxman

The Veteran’s Administration has responded to the vast needs of justice-involved veterans through the Veteran’s Justice Program (VJP), which includes both the Veterans Justice Outreach (VJO) program and the Health Care for Re-Entry Veterans (HCRV) program. The Veterans Justice Outreach program provides Veterans Justice Outreach (VJO) Specialists to coordinate service delivery for justice involved veterans;…

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Measuring Community Vulnerability to COVID/OUD (051)

Principal Investigator(s): Marynia Kolak

The COVID-19 pandemic has created many additional challenges for patients with opioid use disorder, including disrupted treatment and support systems, mental health issues related with social distancing, as well as increasing financial and economic stressors. Applying a racial, social, and spatial equity lens, this project first develops a new COVID-19 community typology measures considering county…

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Survey of Turnkey Clinics Staff (050)

Principal Investigator(s): Bruce Taylor

Correctional medical staff have been on the front lines of the current COVID-19 pandemic. Medical staff working in prisons and jails are responsible for providing healthcare in very challenging correctional environments. As county jails have been among the hotspots for COVID-19 related outbreaks, it is imperative to better understand perceptions of COVID-19 related risk, experiences…

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Evaluation of MOUD Implementation in VT Corrections (049)

Principal Investigator(s): Elias Klemperer, Ph.D.

Through the NIH Rapid Acceleration of Diagnostics Underserved Populations (RADx-UP) program, Yale University received a supplement to support a study to increase the reach, access, uptake, and impact of COVID-19 testing and to mitigate the impact of COVID-19 among incarcerated people and corrections staff. The initiative’s multidisciplinary team will be working with jails and prisons across Florida, Rhode Island, Minnesota, and Washington to address the urgent need for the development and implementation of long-term COVID-19 testing and prevention strategies. The long-term goal is to mitigate the impact of  COVID-19 in correctional facilities while considering the ethical issues that must be addressed to optimize implementation and effectiveness.

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Teleservices in Judicially Led Diversion Programs (048)

Principal Investigator(s): Tara Kunkel

J-RIG funding supports research into teleservice practices within Judicially Led Diversion Programs (JLDPs) since the pandemic. Judicially led diversion is an umbrella term that encompasses drug courts, opioid courts, and recovery-oriented compliance dockets. While these models differ in design, they share the common features of early intervention, supervision, consistent judicial oversight, and an emphasis on…

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CARE: Testing a Mobile App for Drug Court/Treatment Participants (047)

Principal Investigator(s): Jessica Hulsey

The success of digital therapeutics and telehealth are empirically well documented. What is less understood is what is needed to successfully adopt, sustain, and scale up these efforts in criminal justice settings to maximize both availability and effectiveness. Making evidence-based technology available to particularly vulnerable populations during the pandemic is important and justice-involved substance use…

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Leveraging Social Networks to Increase COVID-19 Testing Uptake (046)

Principal Investigator(s): Katherine Elkington, Ph.D.

This study will research the efficacy and sustainability of a community-social network outreach model that partners infectious disease health providers with community-based organizations to successfully implement (reach, uptake, delivery and sustainment) COVID-19 point of service, rapid-testing among a highly vulnerable and often underserved population, those who use opioids and other substances. Two distinct social network…

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COVID-19 Testing and Prevention in Correctional Settings (045)

Principal Investigator(s): Lauren Brinkley-Rubinstein, Rosemarie Martin, PhD, Emily Wang

Through the NIH Rapid Acceleration of Diagnostics Underserved Populations (RADx-UP) program, Yale University received a supplement to support a study to increase the reach, access, uptake, and impact of COVID-19 testing and to mitigate the impact of COVID-19 among incarcerated people and corrections staff. The initiative’s multidisciplinary team will be working with jails and prisons across Florida, Rhode Island, Minnesota, and Washington to address the urgent need for the development and implementation of long-term COVID-19 testing and prevention strategies. The long-term goal is to mitigate the impact of  COVID-19 in correctional facilities while considering the ethical issues that must be addressed to optimize implementation and effectiveness.

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Community Network-Driven COVID-19 Testing in Vulnerable Populations (044)

Principal Investigator(s): Harold Pollack, PhD, John Schneider, Mai Pho

The University of Chicago received a supplement from NIH Rapid Acceleration of Diagnostics Underserved Populations (RADx-UP) program to support the Community Network-Driven COVID-19 Testing of Vulnerable Populations in the Central US (C3) project to evaluate a COVID-19 testing approach that combines Social Network Testing Strategy (SNS) with community-developed public health messages. This study will focus on addressing misinformation, stigma, and distrust about COVID-19 testing and prevention among two populations that have been particularly hard hit by the pandemic: individuals involved in the criminal justice system that are not currently incarcerated and low-income Latinx individuals. The study will be conducted in rural and urban sites across Texas, Louisiana, Arkansas, Indiana, and Illinois. The goal of this study is to address challenges of current COVID-19 testing strategies which are limited by misinformation, stigma, distrust, and limited affirmation of ability to prevent COVID-19.

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Policy Surveillance for OUD/Justice/COVID (043)

Principal Investigator(s): Rosemarie Martin, PhD

COVID-19 threatens to exacerbate the ongoing opioid epidemic in the United States, but the pandemic has also provided an opportunity to experiment with changes in how opioid treatment services are delivered around the country. The current pandemic has resulted in a flurry of unprecedented policy measures, and it is crucial to understand the impact that rapid changes in law, regulation, and policy are having on individuals with opioid use disorder (OUD), particularly those involved with the criminal justice system.

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ACTION: Addressing Risk through Community Treatment for Infectious Disease Now (042)

Principal Investigator(s): Kevin Knight, Sandra Springer, MD, Ank Nijhawan

Improving HIV and Opioid Use Disorder (OUD) management and implementation for criminal justice (CJ)- involved individuals requires effective approaches to screening, linkage and adherence to integrated services across community agencies and service providers. Community reentry represents a critical opportunity to link individuals to HIV prevention and treatment and OUD service providers. In response, Yale University is conducting a effectiveness-implementation random control trial study to compare two models [Patient Navigation (PN) or Mobile Health Unit (MHU) service delivery] of linking individuals recently released from prison and jail to the continuum of community-based HIV and OUD prevention and treatment service cascades of care.

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NIATx vs ECHO as Comparative Implementation Strategies (041)

Principal Investigator(s): Todd Molfenter, Ph.D., Faye Taxman

The trial will test two timely and successful evidence-based implementation practices, NIATx Coaching and Extension for Community Healthcare Outcomes (ECHO), with jail and community-based treatment providers to increase MOUD use with justice populations. NIATx Coaches provide expertise in MOUD implementation and organizational change to help treatment organizations and staff make, sustain, and spread MOUD. The ECHO platform focuses on the provider side by connecting primary care providers with expert MOUD prescribers to promote high-quality MOUD practices. This will be the first trial that assesses the comparative effectiveness of these approaches overall, and in justice settings.

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Reducing Opioid Mortality in Illinois (ROMI) (040)

Principal Investigator(s): Harold Pollack, PhD, John Schneider, Mai Pho

This study is conducting a multi-site trial called ROMI (Reducing Opioid Mortality in Illinois) to study the effectiveness of case management approaches to link individuals with community-based treatment services upon release from jail. The ROMI intervention includes peer recovery coaches to improve linkages to medications for opioid use disorder (MOUD), supportive services, naloxone distribution, and harm reduction services for justice-involved individuals with opioid use disorder (OUD).

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Organizational Linkage + Peer Support in Community Corrections (039)

Principal Investigator(s): Damaris Rohsenow, Lauren Brinkley-Rubinstein, Rosemarie Martin, PhD

This study will rigorously test a systems-change approach for increasing the use of medications for opioid use disorder (MOUD) in seven community supervision sites in Rhode Island, North Carolina, and Pennsylvania. The study uses facilitated local change teams consisting of justice and community service providers to develop and implement interorganizational linkage strategies.

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Transitions Clinic Network vs Standard Care at Re-Entry (038)

Principal Investigator(s): Emily Wang

The study will assess whether the Transitions Clinic Network (TCN) program, which provides enhanced primary care and OUD treatment for people recently released from incarceration, improves services along the opioid treatment cascade. In TCN, formerly incarcerated community health workers are embedded within primary care teams and address social determinants of OUD, provide social support, help patients build trust in the health system, and advocate in interactions with the criminal justice system.

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Vertical vs Horizontal Implementation of O-TLM (037)

Principal Investigator(s): Danica Knight, David Olson, Kevin Knight, Noah Painter-Davis

This study is testing two different strategies to implement an Opioid Treatment Linkage Model (O-TLM). The model is designed to link individuals under community supervision with appropriate community-based treatment services. O-TLM seeks to improve interagency collaboration through staff training and cross-system data sharing.

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Testing a Learning Health System in Juvenile Justice Settings (036)

Principal Investigator(s): Matt Aalsma

This study aims to improve treatment linkages and care coordination within the eight juvenile justice systems across Indiana. To address current gaps, the study is implementing a Learning Health System (LHS) to improve collaboration between juvenile justice agencies and community mental health centers, using interagency data-sharing to help identify gaps and opportunities to implement evidence-based interventions.

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Testing XR:NTX vs XR:B (Sublocade) (035)

Principal Investigator(s): David Farabee, Elizabeth Waddell, Josh Lee, Lisa Marsch, Robert Schwartz, Sandra Springer

This study is conducting a large multisite trial to compare the effectiveness of extended-release buprenorphine (Sublocade, XR-B) to extended-release naltrexone (XR-NTX). The trial will enroll individuals prior to release from jail and randomize to either medication option. The first dose of medication will be administered prior to release, with an additional 24 weeks of treatment received in the community.

Participating jails are located in Connecticut, Delaware, New Hampshire, New Jersey and Oregon. The study will measure retention in treatment, and opioid and other substance use outcomes between the two medication conditions, as well as a sample of individuals who opt for other treatment options (“treatment as usual”).

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XR:NTX vs XR:B (Brixadi) (034)

Principal Investigator(s): Shannon Mitchell, Michael Gordon, DPA

This study is conducting a comparative effectiveness trial of extended-release naltrexone (XR-NTX) versus a new extended-release formulation of buprenorphine (Brixadi, XR-B) to treat opioid use disorder (OUD) among justice-involved individuals in ten Maryland county jails.

Participants will be randomly assigned to receive either XR-NTX or XR-B prior to release from jail, followed by six monthly injections while in the community. The goal of the study is to evaluate the effectiveness of the two medications, measure medication adherence, and gather data to inform broader scale-up of medications for opioid use disorder (MOUD) in jails and in the community.

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