This publication describes considerations for the integration of technologies that have become prevalent due to the COVID-19 pandemic (i.e., telemedicine, social media, apps, chatbots, biosensors) and extensions of those technologies into HIV care and research. Although it is not clear how these technologies will change post-pandemic, the most effective systems should combine these technologies due to their complementary features. However, issues involving ethics, risk monitoring, patient engagement, costs, and staffing requirements need to be addressed before the implementation of widespread systems.